The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

被引：117

作者：

Lupher, ML

Rao, N

Eck, MJ

Band, H

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[3] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-5699(99)01484-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

引用

页码：375 / 382

页数：8

共 62 条

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