Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells

被引：71

作者：

Tamanoi, F ^{[1
]}

Gau, CL ^{[1
]}

Jiang, C ^{[1
]}

Edamatsu, H ^{[1
]}

Kato-Stankiewicz, J ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2001年 / 58卷 / 11期

关键词：

protein farnesylation; farnesyltransferase inhibitor; cell cycle; apoptosis;

D O I：

10.1007/PL00000802

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein farnesylation, catalyzed by protein farnesyltransferase, plays important roles in the membrane association and protein-protein interaction of a number of eukaryotic proteins. Recent development of farnesyltransferase inhibitors (FTIs) has led to further insight into the biological significance of farnesylation in cancer cells. A number of reports point to the dramatic effects FTIs exert on cancer cells. In addition to inhibiting anchorage-independent growth, FTIs cause changes in the cell cycle either at the G1/S or at the G2/M phase. Furthermore, induction of apoptosis by FTIs has been reported. FTIs also affects the actin cytoskeleton and cell morphology. This review summarizes these reports and discusses implications for farnesylated proteins responsible for these FTI effects.

引用

页码：1636 / 1649

页数：14

共 106 条

[81]

SATTLER I, 1996, REGULATION RAS SIGNA, P95

[82] REGULATION OF CELL-PROLIFERATION BY EPIDERMAL GROWTH-FACTOR [J].