Identification of six taxine alkaloids from Taxus baccata needles

被引：50

作者：

Jenniskens, LHD

vanRozendaal, ELM

vanBeek, TA

Wiegerinck, PHG

Scheeren, HW

机构：

[1] AGR UNIV WAGENINGEN,DEPT ORGAN CHEM,PHYTOCHEM SECT,6703 HB WAGENINGEN,NETHERLANDS

[2] NSR CTR MOLEC STRUCT DESIGN & SYNTH,DEPT ORGAN CHEM,6525 ED NIJMEGEN,NETHERLANDS

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 02期

关键词：

D O I：

10.1021/np960033l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six taxine alkaloids were isolated from Taxus baccata needles and partially separated. An HPLC method for the analysis of the taxine fraction was developed. By NMR and deamination/hydrolysis studies it was established that the taxine fraction consisted mostly of taxicin-I and taxicin-II derivatives in a variable ratio. Four of the six taxine alkaloids isolated have not been reported before. All of the alkaloids were found to be unstable under neutral and basic conditions, and some of them were very easily interconverted.

引用

页码：117 / 123

页数：7

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