The role of double-strand break repair - insights from human genetics

被引：429

作者：

O'Driscoll, M ^{[1
]}

Jeggo, PA ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

NATURE REVIEWS GENETICS | 2006年 / 7卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrg1746

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.

引用

页码：45 / 54

页数：10

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