Semliki Forest virus strongly reduces mosquito host defence signaling

被引：73

作者：

Fragkoudis, R. ^{[1
,2
]}

Chi, Y. ^{[1
,2
]}

Siu, R. W. C. ^{[1
,2
]}

Barry, G. ^{[1
,2
]}

Attarzadeh-Yazdi, G. ^{[1
,2
]}

Merits, A. ^{[3
]}

Nash, A. A. ^{[1
,2
]}

Fazakerley, J. K. ^{[1
,2
]}

Kohl, A. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Royal Dick Sch Vet Studies, Coll Med & Vet Med, Edinburgh EH9 1QH, Midlothian, Scotland

[2] Univ Edinburgh, Coll Med & Vet Med, Roslin Inst, Edinburgh EH9 1QH, Midlothian, Scotland

[3] Univ Tartu, Inst Technol, EE-50411 Tartu, Estonia

来源：

INSECT MOLECULAR BIOLOGY | 2008年 / 17卷 / 06期

基金：

英国惠康基金;

关键词：

Semliki Forest virus; mosquito cells; host response; cell signaling; virus; host interactions;

D O I：

10.1111/j.1365-2583.2008.00834.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Alphavirus genus within the Togaviridae family contains several important mosquito-borne arboviruses. Other than the antiviral activity of RNAi, relatively little is known about alphavirus interactions with insect cell defences. Here we show that Semliki Forest virus (SFV) infection of Aedes albopictus-derived U4.4 mosquito cells reduces cellular gene expression. Activation prior to SFV infection of pathways involving STAT/IMD, but not Toll signaling reduced subsequent virus gene expression and RNA levels. These pathways are therefore not only able to mediate protective responses against bacteria but also arboviruses. However, SFV infection of mosquito cells did not result in activation of any of these pathways and suppressed their subsequent activation by other stimuli.

引用

页码：647 / 656

页数：10

共 75 条

[1] Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression [J].