Antiviral drug susceptibility assays: going with the flow

被引：12

作者：

McSharry, JJ ^{[1
]}

机构：

[1] Albany Med Coll, Albany, NY 12208 USA

来源：

ANTIVIRAL RESEARCH | 1999年 / 43卷 / 01期

关键词：

antiviral drugs; drug susceptibility assays; flow cytometry;

D O I：

10.1016/S0166-3542(99)00039-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review describes the procedures for the use of fluorochrome labeled monoclonal antibodies and Row cytometry for the detection and quantification of virus infected cells. The application of this technology for (1) identifying virus infected cells in clinical specimens obtained from human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) infected individuals; (2) screening antiviral compounds active against HCMV, HDSV and HIV; and (3) performing drug susceptibility testing for HCMV, HSV and HIV clinical isolates are reviewed. The flow cytometry drug susceptibility assay is rapid, quantitative, and easily performed. It should be considered by anyone interested in performing drug susceptibility testing for any virus for which there are reliable monoclonal antibodies. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 21

页数：21

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