Antibiotic prophylaxis with a single dose of cefazolin during pacemaker implantation: Incidence of long-term infective complications

被引:35
作者
Bertaglia, E
Zerbo, F
Zardo, S
Barzan, D
Zoppo, F
Pascotto, P
机构
[1] Osped Civile, Serv Farm, Mirano, VE, Italy
[2] Osped Civile, Dipartimento Cardiol, Mirano, VE, Italy
来源
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 2006年 / 29卷 / 01期
关键词
D O I
10.1111/j.1540-8159.2006.00294.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Systemic and localized infections related to permanent pacemaker implantation are not common, but are serious and potentially life-threatening complications. The aims of this prospective observational study were: (1) to assess the safety and long-term efficacy of a simplified scheme of antibiotic prophylaxis, and (2) to identify the predictors of long-term infective complications, inpatients undergoing pacemaker implantation or replacement. Methods and Results: From October 1998 to July 2001, 852 patients (mean age 77.0 +/- 9.2 years; 474 men) who underwent new permanent pacemaker implantation (69.6%) or pulse generator replacement (30.4%) received a mini-bag of 2 g of cefazolin diluted in 50 mL of saline solution, administered intravenously in 20 minutes before the beginning of the procedure. Early (within 2 months of implantation) and late major and minor infective complications were recorded. During the earlier phase, minor complications were observed in 9 patients (1%). During the long-term phase of the surveillance (mean 25.6 +/- 11.0 months, range 12-55 months) major infective complications were observed in 6 patients (0.7%). On multivariate analysis, no clinical or procedural variable predicted the occurrence of long-term infective complications. Conclusions: Our data indicate the safety and efficacy of a single, intravenous 2 g dose of cefazolin in preventing infective complications related to pacemaker implantation or replacement. No clinical or procedural variable predicted the occurrence of long-term infective complications.
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页码:29 / 33
页数:5
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