Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors

被引：8

作者：

Martinez, A

Gil, C

Perez, C

Castro, A

Prieto, C

Otero, J

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[2] Hosp Doce Octubre, Microbiol Serv, Unidad Virol, Madrid 28041, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00538-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modifications of our previously reported lead compounds, acyclonucleosides derived from 2,1,3-benzothiadiazine dioxides, in the search for inhibitors of human cytomegalovirus (HCMV), lead us to identify the chlorophenylmethyl benzothiadiazine dioxides derivatives as potent HCMV inhibitors. The synthesis and antiviral data of this second-generation of benzothiadiazine dioxide compounds are reported. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3133 / 3136

页数：4

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