Hydrogen bond catalyzed enantioselective vinylogous Mukaiyama aldol reaction

被引：90

作者：

Gondi, VB ^{[1
]}

Gravel, M ^{[1
]}

Rawal, VH ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 25期

关键词：

D O I：

10.1021/ol052301p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The concept of hydrogen bonding catalysis was extended to the vinylogous Mukaiyama aldol reaction, which gives rapid access to polyketide derivatives. The reaction of the silyldienol ether shown and a range of aldehydes catalyzed by TADDOL proceeds regiospecifically to produce the addition products in good yields and enantiomeric excesses.

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页码：5657 / 5660

页数：4

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