Asymmetric reduction of acetophenone in membrane reactors: comparison of oxazaborolidine and alcohol dehydrogenase catalysed processes

被引：51

作者：

Rissom, S ^{[1
]}

Beliczey, J ^{[1
]}

Giffels, G ^{[1
]}

Kragl, U ^{[1
]}

Wandrey, C ^{[1
]}

机构：

[1] Forschungszentrum Julich, Inst Biotechnol, D-52425 Julich, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(99)00050-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective reduction of acetophenone was studied in two different ways. Chemical borane reduction using a homogeneously soluble polymer-bound oxazaborolidine catalyst was carried out in a continuously operated membrane reactor and yielded (R)-phenylethanol in good enantiomeric excess with high space-time yields. An enzymatic reduction using a dehydrogenase two-enzyme system as the catalyst and formate as the hydrogen source was carried out in an extractive bi-membrane reactor and yielded (S)-phenylethanol in excellent enantiomeric excess with a low enzyme consumption. A comparison of the two systems with respect to space-time yield, total turnover number and other parameters is made. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：923 / 928

页数：6

共 25 条

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