Placental mRNA expression of α and β human chorionic gonadotrophin in early trisomy 18 pregnancies

被引：7

作者：

Brizot, Maria L. ^{[1
]}

Jauniaux, Eric ^{[1
]}

Mckie, Andrew T. ^{[2
]}

Farzaneh, Farzin ^{[2
]}

Nicolaides, Kypros H. ^{[1
]}

机构：

[1] Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, Med Sch, London, England

[2] Kings Coll Hosp, Dept Mol Med, Med Sch, London, England

来源：

MOLECULAR HUMAN REPRODUCTION | 1996年 / 2卷 / 06期

关键词：

gene expression; human chorionic gonadotrophin; trisomy; 18;

D O I：

10.1093/molehr/2.6.463

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The placental expression of human chorionic gonadotrophin (HCG) I- and beta-subunits was investigated in eight pregnancies presenting with trisomy 18 and in 30 normal pregnancies at 11-15 weeks gestation. In the control group, the median densitometric scores of placental beta-HCG and beta-HCG mRNA were 1.23 and 1.74 respectively. In the trisomy 18 group the median 13-HCG mRNA was significantly lower (0.16, Z = 2.29, P < 0.05) but alpha-HCG 0.60, Z = 1.75, P = 0.08) was not significantly different from normal. These findings suggest that in trisomy 18 the decrease in maternal serum concentration of HCG subunits results from an impairment in the transcription of the corresponding gene which affects the beta subunit to a greater extent than the I subunit.

引用

页码：463 / 465

页数：3

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