Direct role of human dermal fibroblasts and indirect participation of epidermal keratinocytes in MMP-1 production after UV-B irradiation

被引：99

作者：

Fagot, D ^{[1
]}

Asselineau, D ^{[1
]}

Bernerd, F ^{[1
]}

机构：

[1] LOreal, Adv Res Labs, Ctr Charles Zviak, F-92583 Clichy, France

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2002年 / 293卷 / 11期

关键词：

ultraviolet-B; matrix-metalloproteinase; keratinocytes; fibroblasts; soluble factors; paracrine mechanism;

D O I：

10.1007/s00403-001-0271-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In vivo, matrix metalloproteinases are produced in response to ultraviolet B (UV-B) irradiation and are considered to be involved in connective tissue alterations observed in photoaging. The respective roles of keratinocytes and fibroblasts in UV-B-induced MMP-1 production were investigated in monolayer cultures of keratinocytes and fibroblasts as well as in an epidermis model reconstructed in vitro. In contrast to fibroblasts, which secreted MMP-1 in response to UV-B irradiation, no accumulation of MMP-1 was observed after UV-B irradiation of keratinocytes. However, culture medium from UV-B-irradiated keratinocytes, which showed an increase in IL-1alpha and IL-6, induced MMP-1 production by human fibroblasts, suggesting that UV-B irradiation modulates MMP-1 production via both direct and indirect mechanisms.

引用

页码：576 / 583

页数：8

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