Direct role of human dermal fibroblasts and indirect participation of epidermal keratinocytes in MMP-1 production after UV-B irradiation

被引：99

作者：

Fagot, D ^{[1
]}

Asselineau, D ^{[1
]}

Bernerd, F ^{[1
]}

机构：

[1] LOreal, Adv Res Labs, Ctr Charles Zviak, F-92583 Clichy, France

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2002年 / 293卷 / 11期

关键词：

ultraviolet-B; matrix-metalloproteinase; keratinocytes; fibroblasts; soluble factors; paracrine mechanism;

D O I：

10.1007/s00403-001-0271-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In vivo, matrix metalloproteinases are produced in response to ultraviolet B (UV-B) irradiation and are considered to be involved in connective tissue alterations observed in photoaging. The respective roles of keratinocytes and fibroblasts in UV-B-induced MMP-1 production were investigated in monolayer cultures of keratinocytes and fibroblasts as well as in an epidermis model reconstructed in vitro. In contrast to fibroblasts, which secreted MMP-1 in response to UV-B irradiation, no accumulation of MMP-1 was observed after UV-B irradiation of keratinocytes. However, culture medium from UV-B-irradiated keratinocytes, which showed an increase in IL-1alpha and IL-6, induced MMP-1 production by human fibroblasts, suggesting that UV-B irradiation modulates MMP-1 production via both direct and indirect mechanisms.

引用

页码：576 / 583

页数：8

共 44 条

[21]

Kondo S, 1997, J CELL PHYSIOL, V171, P190, DOI 10.1002/(SICI)1097-4652(199705)171:2<190::AID-JCP9>3.0.CO

[22]

2-J

[23]

Kondo S, 1994, Exp Dermatol, V3, P29, DOI 10.1111/j.1600-0625.1994.tb00263.x

[24]

KOOB TJ, 1980, BIOCHIM BIOPHYS ACTA, V629, P13, DOI 10.1016/0304-4165(80)90260-3

[25] WAVELENGTH DEPENDENT FORMATION OF THYMINE DIMERS AND (6-4)PHOTOPRODUCTS IN DNA BY MONOCHROMATIC ULTRAVIOLET-LIGHT RANGING FROM 150 TO 365 NM [J].

MATSUNAGA, T ;

HIEDA, K ;

NIKAIDO, O .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1991, 54 (03) :403-410

[26]

MCKENZIE RC, 1994, PHOTODERMATOL PHOTO, V10, P74

[27] CHRONIC SOLAR DERMATOSIS - A LIGHT AND ELECTRON MICROSCOPIC STUDY OF DERMIS [J].

MITCHELL, RE .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1967, 48 (03) :203-+

[28]

MURPHY G, 1991, British Journal of Rheumatology, V30, P25

[29]

PETERSEN MJ, 1987, J BIOL CHEM, V262, P835

[30] CONSTITUTIVE PRODUCTION OF PROCOLLAGENASE AND TISSUE INHIBITOR OF METALLOPROTEINASES BY HUMAN KERATINOCYTES IN CULTURE [J].

PETERSEN, MJ ;

WOODLEY, DT ;

STRICKLIN, GP ;

OKEEFE, EJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 92 (02) :156-159

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