Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception A Systematic Review and Meta-analysis

被引:103
作者
Hvidtjorn, Dorte [1 ]
Schieve, Laura [2 ]
Schendel, Diana [2 ]
Jacobsson, Bo [1 ,3 ,4 ]
Svaerke, Claus [1 ]
Thorsen, Poul [1 ,5 ]
机构
[1] Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, DK-8000 Aarhus C, Denmark
[2] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
[3] Univ Gothenburg, Dept Obstet & Gynecol, Perinatal Ctr, Inst Hlth Women & Children,Sahlgrenska Acad, Gothenburg, Sweden
[4] Univ Oslo, Rikshosp, Dept Obstet & Gynecol, N-0027 Oslo, Norway
[5] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
来源
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE | 2009年 / 163卷 / 01期
关键词
IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION; PERINATAL RISK-FACTORS; FOLLOW-UP; REPRODUCTIVE TECHNOLOGY; OBSTETRIC COMPLICATIONS; NEUROLOGICAL SEQUELAE; COGNITIVE-DEVELOPMENT; SINGLETON CHILDREN; EUROPEAN REGISTERS;
D O I
10.1001/archpediatrics.2008.507
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To assess the existing evidence of associations between assisted conception and cerebral palsy (CP), autism spectrum disorders (ASD), and developmental delay. Data Sources: Forty-one studies identified in a systematical PubMed and Excerpta Medica Database (EMBASE) search for articles published from January 1, 1996, to April 1, 2008. Study Selection: Studies written in English comparing children born after assisted conception with children born after natural conception assessing CP, ASD, and developmental delay, based on original data with a follow-up of 1 year or more. Main Exposures: In vitro fertilization (IVF) with or without intracytoplasmic sperm injection or ovulation induction with or without subsequent intrauterine insemination. Main Outcome Measures: Cerebral palsy, ASD, and developmental delay. Results: Nine CP studies showed that children born after IVF had an increased risk of CP associated with preterm delivery. In our meta-analysis including 19 462 children exposed to IVF, we estimated a crude odds ratio of 2.18 (95% confidence interval, 1.71-2.77). Eight ASD studies and 30 studies on developmental delay showed inconsistent results. No studies assessed the risk of CP, ASD, or developmental delay in children born after ovulation induction exclusively. Conclusions: Methodological problems were revealed in the identified studies, and the gaps in our knowledge about the long-term outcomes of children born after assisted conception are considerable, including a lack of information on the long-term consequences of ovulation induction. Possible associations with ASD and developmental delay need assessment in larger studies. Studies on assisted conception and CP from countries outside of Scandinavia are needed, including detailed information on time to pregnancy, underlying cause of infertility, and type of IVF treatment.
引用
收藏
页码:72 / 83
页数:12
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