Role of Gap Junctions in Embryonic and Somatic Stem Cells

被引：57

作者：

Wong, Raymond C. B. ^{[1
]}

Pera, Martin F. ^{[2
]}

Pebay, Alice ^{[3
,4
]}

机构：

[1] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA

[2] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 USA

[3] Univ Melbourne, Dept Neurosci, Parkville, Vic 3052, Australia

[4] Univ Melbourne, Dept Pharmacol, Parkville, Vic 3052, Australia

来源：

STEM CELL REVIEWS | 2008年 / 4卷 / 04期

基金：

英国医学研究理事会;

关键词：

Somatic stem cells; Neural stem cells; Hematopoietic stem cells; Mesenchymal stem cells; Embryonic stem cells; Gap junctions; Gap junctional intercellular communication;

D O I：

10.1007/s12015-008-9038-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells provide an invaluable tool to develop cell replacement therapies for a range of serious disorders caused by cell damage or degeneration. Much research in the field is focused on the identification of signals that either maintain stem cell pluripotency or direct their differentiation. Understanding how stem cells communicate within their microenvironment is essential to achieve their therapeutic potentials. Gap junctional intercellular communication (GJIC) has been described in embryonic stem cells (ES cells) and various somatic stem cells. GJIC has been implicated in regulating different biological events in many stem cells, including cell proliferation, differentiation and apoptosis. This review summarizes the current understanding of gap junctions in both embryonic and somatic stem cells, as well as their potential role in growth control and cellular differentiation.

引用

页码：283 / 292

页数：10

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