Synthesis of N-phenyl-substituted derivatives of morphine alkaloids

被引：11

作者：

Moiseev, SK

Bakhanova, IV

Schmidhammer, H

Kalinin, VN

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia

[2] Univ Innsbruck, Inst Pharmaceut Chem, A-6020 Innsbruck, Austria

来源：

RUSSIAN CHEMICAL BULLETIN | 1999年 / 48卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

thebaine; morphine alkaloids; arylation; triphenylbismuth;

D O I：

10.1007/BF02496186

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the preparation of N-phenyl-substituted morphine alkaloids by treatment of the corresponding N-nor derivatives with Ph3Bi in the presence of Cu(OAc)(2) is proposed. 17-Nor-17-phenylthebaine thus obtained can serve as a convenient starting material for the preparation of other N-phenyl-substituted alkaloids.

引用

收藏

页码：589 / 592

页数：4

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