Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin

被引:216
作者
Sakoulas, G
Alder, J
Thauvin-Eliopouios, C
Moellering, RC
Eliopoulos, GM
机构
[1] New York Med Coll, Dept Med, Div Infect Dis, Valhalla, NY 10595 USA
[2] Westchester Cty Med Ctr, Valhalla, NY 10595 USA
[3] Cubist Pharmaceut, Lexington, MA USA
[4] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1128/AAC.50.4.1581-1585.2006
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We studied vancomycin and daptomycin susceptibility in methicillin-resistant Staphylococcus aureus from patients exposed to vancomycin, glycopeptide-intermediate S. aureus, and S. aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin.
引用
收藏
页码:1581 / 1585
页数:5
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