The role of nitric oxide in articular cartilage damage

被引：149

作者：

Lotz, M ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, Div Arthrit Res, La Jolla, CA 92037 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1999年 / 25卷 / 02期

关键词：

D O I：

10.1016/S0889-857X(05)70067-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Different experimental approaches have been used to examine the role of nitric oxide (NO) in cartilage degradation. Studies on cultured cartilage and isolated chondrocytes addressed the effects of endogenous and exogenous NO on cell function. Cartilage from arthritic joints was analyzed for evidence of NO production. Ln vivo studies used experimental models of arthritis and mice with a gene knockout of inducible NO synthase to elucidate the role of NO in the pathogenesis of arthritis and cartilage destruction. This article summarizes the results of these various lines of research and describes current concepts of the role of NO in cartilage biology and pathophysiology.

引用

页码：269 / +

页数：15

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