Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep

被引：208

作者：

Lightowlers, MW

Jensen, O

Fernandez, E

Iriarte, JA

Woollard, DJ

Cauci, CG

Jenkins, DJ

Heath, DD

机构：

[1] Univ Melbourne, Mol Parasitol Lab, Werribee, Vic 3030, Australia

[2] Program Controle Hydatidosis, RA-9020 Sarmiento, Chubut, Argentina

[3] Univ Patagonia, Fac Ciencias Nat, RA-9100 Piso Trelew, Chubut, Argentina

[4] Australian Hydatid Control & Epidemiol Program, Fyshwick, ACT 2609, Australia

[5] AgRes, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1999年 / 29卷 / 04期

基金：

英国医学研究理事会;

关键词：

Echinococcus granulosus; EG95; hydatid; recombinant antigen; sheep; vaccine;

D O I：

10.1016/S0020-7519(99)00003-X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Experimental vaccine trials against hydatid disease have been undertaken in sheep using the EG95 recombinant vaccine. Challenge infection was with viable Echinococcus granulosus eggs obtained from a New Zealand isolate (dog/sheep cycle), an Australian isolate (dingo/wallaby cycle) and an Argentine isolate (dog/sheep cycle). Vaccination with EG95 conferred a high degree of protection against challenge with all three parasite isolates (protection range 96-100%). Taken together, the trials demonstrated that 86% of vaccinated sheep were completely free of viable hydatid cysts when examined approximately 1 year after challenge infection. Vaccination reduced the number of viable cysts by 99.3% compared with unvaccinated controls. These results suggest that the EG95 vaccine could have wide applicability as a new tool for use in hydatid control campaigns. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：531 / 534

页数：4

共 6 条

[1] GENETIC-VARIANTS WITHIN THE GENUS ECHINOCOCCUS IDENTIFIED BY MITOCHONDRIAL-DNA SEQUENCING [J].