[Hysp2] and [Hap2]didemnin B, two new [Hip2]-modified didemnin B from the tunicate Trididemnum cyanophorum

被引：9

作者：

Banaigs, B ^{[1
]}

Abou Mansour, E ^{[1
]}

Bonnard, I ^{[1
]}

Boulanger, A ^{[1
]}

Francisco, C ^{[1
]}

机构：

[1] Univ Perpignan, Ctr Phytopharm, CNRS, URA 461, F-66860 Perpignan, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 31期

关键词：

marine metabolites; depsipeptides; mass spectrometry; NMR;

D O I：

10.1016/S0040-4020(99)00524-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of two new didemnins ([Hysp(2)]didemnin B and [Hap(2)]didemnin B) from the Aplousobranch ascidian Trididemnum cyanophorum (Didemnidae) are described. Structures are determined by a combination of mass spectrometry and one and two-dimensional high-field NMR techniques. Complete H-1 and C-13 NMR spectral assignments and conformational informations are presented. The cytotoxicities of the compounds towards drug-sensitive and drug-resistant tumor cell lines are: compared with those of didemnins A and B. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：9559 / 9574

页数：16

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