Microcapsule carbon nanotube devices for therapeutic applications

被引：14

作者：

Kulamarva, Arun ^{[1
]}

Raja, Pavan M. V. ^{[2
]}

Bhathena, Jasmine ^{[1
]}

Chen, Hongmei ^{[1
]}

Talapatra, Saikat ^{[3
]}

Ajayan, Pulickel M. ^{[4
]}

Nalamasu, Omkaram ^{[5
]}

Prakash, Satya ^{[1
]}

机构：

[1] McGill Univ, Dept Biomed Engn, Biomed Technol & Cell Therapy Res Lab, Fac Med, Montreal, PQ H3A 2B4, Canada

[2] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

[3] So Illinois Univ, Dept Phys, Carbondale, IL 62901 USA

[4] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA

[5] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA

来源：

NANOTECHNOLOGY | 2009年 / 20卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

MAMMALIAN-CELLS; TARGETED DELIVERY; DRUG-DELIVERY; GENE DELIVERY; PLASMID DNA; IN-VITRO; TRANSLOCATION; COMPOSITES; GROWTH; TISSUE;

D O I：

10.1088/0957-4484/20/2/025612

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Carbon nanotubes are a new class of nanomaterials that have immense potential in the field of biomedicine. Their ability to carry large quantities of therapeutic molecules makes them prime candidates for providing targeted delivery of therapeutics for use in various diseases. However, their utility is limited due to the problems faced during their delivery to target sites. This article for the first time describes the design of a novel microcapsule carbon nanotube targeted delivery device. This device has potential in the targeted delivery of carbon nanotubes in suitable membranes along with their cargo, safely and effectively to the target loci.

引用

页数：7

共 25 条

[1] Nanotubes from carbon [J].

Ajayan, PM .

CHEMICAL REVIEWS, 1999, 99 (07) :1787-1799

[2] Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing [J].

Cai, D ;

Mataraza, JM ;

Qin, ZH ;

Huang, ZP ;

Huang, JY ;

Chiles, TC ;

Carnahan, D ;

Kempa, K ;

Ren, ZF .

NATURE METHODS, 2005, 2 (06) :449-454

[3] Carbon nanotube delivery of the GFP gene into mammalian cells [J].

Gao, LZ ;

Nie, L ;

Wang, TH ;

Qin, YJ ;

Guo, ZX ;

Yang, DL ;

Yan, XY .

CHEMBIOCHEM, 2006, 7 (02) :239-242

[4] Chemically functionalized carbon nanotubes as substrates for neuronal growth [J].

Hu, H ;

Ni, YC ;

Montana, V ;

Haddon, RC ;

Parpura, V .

NANO LETTERS, 2004, 4 (03) :507-511

[5] Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells [J].

Kam, NWS ;

Jessop, TC ;

Wender, PA ;

Dai, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (22) :6850-6851

[6] Responsive polymeric delivery systems [J].

Kost, J ;

Langer, R .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 46 (1-3) :125-148

[7] MICROENCAPSULATED ISLETS AS BIOARTIFICIAL ENDOCRINE PANCREAS [J].

LIM, F ;

SUN, AM .

SCIENCE, 1980, 210 (4472) :908-910

[8] RNA polymer translocation with single-walled carbon nanotubes [J].

Lu, Q ;

Moore, JM ;

Huang, G ;

Mount, AS ;

Rao, AM ;

Larcom, LL ;

Ke, PC .

NANO LETTERS, 2004, 4 (12) :2473-2477

[9] Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles [J].

Mladenovska, K. ;

Raicki, R. S. ;

Janevik, E. I. ;

Ristoski, T. ;

Pavlova, M. J. ;

Kavrakovski, Z. ;

Dodov, M. G. ;

Goracinova, K. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 342 (1-2) :124-136

[10] Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy [J].

Orive, G ;

Tam, SK ;

Pedraz, JL ;

Hallé, JP .

BIOMATERIALS, 2006, 27 (20) :3691-3700

← 1 2 3 →