Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy

被引：274

作者：

Orive, G ^{[1
]}

Tam, SK ^{[1
]}

Pedraz, JL ^{[1
]}

Hallé, JP ^{[1
]}

机构：

[1] Univ Montreal, Hop Maison Neuve Rosemont, Res Ctr, Montreal, PQ H1T 2M4, Canada

来源：

BIOMATERIALS | 2006年 / 27卷 / 20期

关键词：

alginate; microencapsulation; biocompatibility; purification; poly-L-lysine; islets of Langerhans;

D O I：

10.1016/j.biomaterials.2006.02.048

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cell microencapsulation holds promise for the treatment of many diseases by the continuous delivery of therapeutic products. The biocompatibility of the microcapsules and their biomaterials components is a critical issue for the long-term efficacy of this technology. The objective of this paper is to provide detailed information about the principal factors affecting the biocompatibility of alginates and alginate-poly-L-lysine microcapsules, which are the most frequently employed biomaterials and encapsulation devices for cell immobilization, respectively. Some of these factors include the alginate composition and purification, the selection of the polycation, the interactions between the alginates and the polycation, the microcapsule fabrication process, the uniformity of the devices and the implantation procedure. Improved knowledge will lead to the production of standardized transplantation-grade biomaterials and biocompatible microcapsules. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3691 / 3700

页数：10

共 69 条

[1] Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants [J].