Characterization of seven murine caspase family members

被引：184

作者：

Van de Craen, M

Vandenabeele, P

Declercq, W

Van den Brande, I

Van Loo, G

Molemans, F

Schotte, P

Van Criekinge, W

Beyaert, R

Fiers, W

机构：

[1] FLANDERS INTERUNIV INST BIOTECHNOL, MOL BIOL LAB, B-9000 GHENT, BELGIUM

[2] STATE UNIV GHENT, B-9000 GHENT, BELGIUM

来源：

FEBS LETTERS | 1997年 / 403卷 / 01期

关键词：

caspase; interleukin-1; family PCR cloning; tissue expression;

D O I：

10.1016/S0014-5793(97)00026-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven members of the murine caspase (mCASP) family mere cloned and functionally characterized by transient overexpression: mCASP-1 (mICE), mCASP-2 (Ich1), mCASP-3 (CPP32), mCASP-6 (Mch2), mCASP-7 (Mch3), mCASP-11 (TX) and mCASP-12. mCASP-11 is presumably the murine homolog of human CASP-4. Although mCASP-12 is related to human CASP-5 (ICE(rel)-III), it is most probably a new CASP-1 family member. On the basis of sequence homology, the caspases can be divided into three subfamilies: first, mCASP-1, mCASP-11 and mCASP-12; second, mCASP-2; third, mCASP-3, mCASP-6 and mCASP-7. The tissue distribution of the CASP-1 subfamily transcripts is more restricted than that of the CASP-3 subfamily transcripts, suggesting that the transcriptional regulation of the CASP members within one subfamily is related, but is quite different between the CASP-1 and the CASP-3 subfamilies. Transient overexpression of each of the seven CASPs induced apoptosis in mammalian cells. Only two, mCASP-1 as well as mCASP-3, mere able to process precursor interleukin (IL)-1 beta to biologically active IL-1 beta. In addition, mCASP-3 is the predominant PARP-cleaving enzyme in vivo. (C) 1997 Federation of European Biochemical Societies.

引用

页码：61 / 69

页数：9

共 50 条

[41] CLUSTAL-W - IMPROVING THE SENSITIVITY OF PROGRESSIVE MULTIPLE SEQUENCE ALIGNMENT THROUGH SEQUENCE WEIGHTING, POSITION-SPECIFIC GAP PENALTIES AND WEIGHT MATRIX CHOICE [J].

THOMPSON, JD ;

HIGGINS, DG ;

GIBSON, TJ .

NUCLEIC ACIDS RESEARCH, 1994, 22 (22) :4673-4680

[42] A NOVEL HETERODIMERIC CYSTEINE PROTEASE IS REQUIRED FOR INTERLEUKIN-1-BETA PROCESSING IN MONOCYTES [J].

THORNBERRY, NA ;

BULL, HG ;

CALAYCAY, JR ;

CHAPMAN, KT ;

HOWARD, AD ;

KOSTURA, MJ ;

MILLER, DK ;

MOLINEAUX, SM ;

WEIDNER, JR ;

AUNINS, J ;

ELLISTON, KO ;

AYALA, JM ;

CASANO, FJ ;

CHIN, J ;

DING, GJF ;

EGGER, LA ;

GAFFNEY, EP ;

LIMJUCO, G ;

PALYHA, OC ;

RAJU, SM ;

ROLANDO, AM ;

SALLEY, JP ;

YAMIN, TT ;

LEE, TD ;

SHIVELY, JE ;

MACCROSS, M ;

MUMFORD, RA ;

SCHMIDT, JA ;

TOCCI, MJ .

NATURE, 1992, 356 (6372) :768-774

[43]

VANHAESEBROECK B, 1991, CANCER RES, V51, P2469

[44] BCL-2 PREVENTS DEATH OF FACTOR-DEPRIVED CELLS BUT FAILS TO PREVENT APOPTOSIS IN TARGETS OF CELL-MEDIATED KILLING [J].

VAUX, DL ;

AGUILA, HL ;

WEISSMAN, IL .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (07) :821-824

[45] CRYSTAL-STRUCTURE OF THE CYSTEINE PROTEASE INTERLEUKIN-1-BETA-CONVERTING ENZYME - A (P20/P10)(2) HOMODIMER [J].

WALKER, NPC ;

TALANIAN, RV ;

BRADY, KD ;

DANG, LC ;

BUMP, NJ ;

FERENZ, CR ;

FRANKLIN, S ;

GHAYUR, T ;

HACKETT, MC ;

HAMMILL, LD ;

HERZOG, L ;

HUGUNIN, M ;

HOUY, W ;

MANKOVICH, JA ;

MCGUINESS, L ;

ORLEWICZ, E ;

PASKIND, M ;

PRATT, CA ;

REIS, P ;

SUMMANI, A ;

TERRANOVA, M ;

WELCH, JP ;

XIONG, L ;

MOLLER, A ;

TRACEY, DE ;

KAMEN, R ;

WONG, WW .

CELL, 1994, 78 (02) :343-352

[46] ICH-1, AN ICE/CED-3-RELATED GENE, ENCODES BOTH POSITIVE AND NEGATIVE REGULATORS OF PROGRAMMED CELL-DEATH [J].

WANG, L ;

MIURA, M ;

BERGERON, L ;

ZHU, H ;

YUAN, JY .

CELL, 1994, 78 (05) :739-750

[47] Identification and characterization of Ich-3, a member of the interleukin-1 beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE [J].

Wang, SY ;

Miura, M ;

Jung, YK ;

Zhu, H ;

Gagliardini, V ;

Shi, LF ;

Greenberg, AH ;

Yuan, JY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20580-20587

[48]

WHITACRE CM, 1995, CANCER RES, V55, P3697

[49] STRUCTURE AND MECHANISM OF INTERLEUKIN-1-BETA CONVERTING-ENZYME [J].

WILSON, KP ;

BLACK, JAF ;

THOMSON, JA ;

KIM, EE ;

GRIFFITH, JP ;

NAVIA, MA ;

MURCKO, MA ;

CHAMBERS, SP ;

ALDAPE, RA ;

RAYBUCK, SA ;

LIVINGSTON, DJ .

NATURE, 1994, 370 (6487) :270-275

[50] THE C-ELEGANS CELL-DEATH GENE CED-3 ENCODES A PROTEIN SIMILAR TO MAMMALIAN INTERLEUKIN-1-BETA-CONVERTING ENZYME [J].

YUAN, JY ;

SHAHAM, S ;

LEDOUX, S ;

ELLIS, HM ;

HORVITZ, HR .

CELL, 1993, 75 (04) :641-652

← 1 2 3 4 5 →