Isoprenoids and Alzheimer's disease: a complex relationship

被引：61

作者：

Cole, SL ^{[1
]}

Vassar, R ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

来源：

NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 02期

关键词：

Alzheimer's disease; statins; isoprenoids; cholesterol; APP; metabolism; A beta; neuroinflammation; TaU;

D O I：

10.1016/j.nbd.2005.11.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which Inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under investigation. Whether statins offer benefit for AD will be determined by the outcome of large, placebo-con trolled, randomized clinical trials. However, their use as pharmacological tools has delineated novel roles for isoprenoids in AD. Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：209 / 222

页数：14

共 140 条

[61] Mutant presenilin (A260V) affects Rab8 in PC12D cell [J].

Kametani, F ;

Usami, M ;

Tanaka, K ;

Kume, H ;

Mori, H .

NEUROCHEMISTRY INTERNATIONAL, 2004, 44 (05) :313-320

[62] Cholesterol is required for surface transport of influenza virus hemagglutinin [J].

Keller, P ;

Simons, K .

JOURNAL OF CELL BIOLOGY, 1998, 140 (06) :1357-1367

[63] Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease [J].

Kivipelto, M ;

Helkala, EL ;

Laakso, MP ;

Hänninen, T ;

Hallikainen, M ;

Alhainen, K ;

Iivonen, S ;

Mannermaa, A ;

Tuomilehto, J ;

Nissinen, A ;

Soininen, H .

ANNALS OF INTERNAL MEDICINE, 2002, 137 (03) :149-155

[64] Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer's disease [J].

Klein, WL ;

Stine, WB ;

Teplow, DB .

NEUROBIOLOGY OF AGING, 2004, 25 (05) :569-580

[65] Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 [J].

Kojro, E ;

Gimpl, G ;

Lammich, S ;

März, W ;

Fahrenholz, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5815-5820

[66] Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease [J].

Kölsch, H ;

Ptok, U ;

Mohamed, I ;

Schmitz, S ;

Rao, ML ;

Maier, W ;

Heun, R .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 121B (01) :128-130

[67] Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production [J].

Kukar, T ;

Murphy, MP ;

Eriksen, JL ;

Sagi, SA ;

Weggen, S ;

Smith, TE ;

Ladd, T ;

Khan, MA ;

Kache, R ;

Beard, J ;

Dodson, M ;

Merit, S ;

Ozols, VV ;

Anastasiadis, PZ ;

Das, P ;

Fauq, A ;

Koo, EH ;

Golde, TE .

NATURE MEDICINE, 2005, 11 (05) :545-550

[68] Statins downregulate myeloperoxidase gene expression in macrophages [J].

Kumar, AP ;

Reynolds, WF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (02) :442-451

[69] Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects [J].

Kumar, B ;

Andreatta, C ;

Koustas, WT ;

Cole, WC ;

Edwards-Prasad, J ;

Prasad, KN .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 68 (05) :627-635

[70]

Kuo YM, 1996, J BIOL CHEM, V271, P4077

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