Mechanisms of disease: breast tumor pathogenesis and the role of the myoepithelial cell

被引：46

作者：

Barsky, SH ^{[1
]}

Karlin, NJ ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA

来源：

NATURE CLINICAL PRACTICE ONCOLOGY | 2006年 / 3卷 / 03期

关键词：

angiogenic inhibitors; breast microenvironment; expression profile; myoepithelial cells; proteinase inhibitors;

D O I：

10.1038/ncponc0450

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer and precancer cells are influenced by important paracrine regulation from the breast microenvironment, which might be as great a determinant of breast cancer behavior as the specific oncogenic or tumor-suppressive alterations occurring within malignant breast cells. Myoepithelial cells exert profound effects on breast tumor cell behavior, and lie in juxtaposition to abnormally proliferating breast epithelial cells in precancerous disease states such as ductal carcinoma in situ ( DCIS). Myoepithelial cells also form a natural border separating breast epithelial cells from stromal angiogenesis. These anatomical relationships suggest that myoepithelial cells might inhibit both the progression of DCIS to invasive breast cancer, and carcinoma-induced angiogenesis.

引用

页码：138 / 151

页数：14

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