Retrograde signaling by endocannabinoids

被引:159
作者
Kreitzer, AC [1 ]
Regehr, WG [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0959-4388(02)00328-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent studies suggest that endocannabinoids act as retrograde messengers at many synapses in the central nervous system. Activation of phospholipases, either through calcium-mediated or receptor-mediated signaling, leads to the formation and release of endocannabinoids. These lipophilic signaling molecules diffuse to nearby presynaptic terminals where they bind to specific G-protein-coupled receptors and inhibit neurotransmitter release for tens of seconds. Thus, an important physiological role of endocannabinoids may be to provide a mechanism by which neurons can rapidly regulate the strength of their synaptic inputs.
引用
收藏
页码:324 / 330
页数:7
相关论文
共 79 条
[1]   RETROGRADE SIGNALING AT GABA(A)-RECEPTOR SYNAPSES IN THE MAMMALIAN CNS [J].
ALGER, BE ;
PITLER, TA .
TRENDS IN NEUROSCIENCES, 1995, 18 (08) :333-340
[2]   The effects of cannabinoids on the brain [J].
Ameri, A .
PROGRESS IN NEUROBIOLOGY, 1999, 58 (04) :315-348
[3]   Interactions between distinct GABAA circuits in hippocampus [J].
Banks, MI ;
White, JA ;
Pearce, RA .
NEURON, 2000, 25 (02) :449-457
[4]   Functional role of high-affinity anandamide transport, as revealed by selective inhibition [J].
Beltramo, M ;
Stella, N ;
Calignano, A ;
Lin, SY ;
Makriyannis, A ;
Piomelli, D .
SCIENCE, 1997, 277 (5329) :1094-1097
[5]  
Cadas H, 1997, J NEUROSCI, V17, P1226
[6]   CANNABINOID RECEPTOR AGONISTS INHIBIT CA CURRENT IN NG108-15 NEUROBLASTOMA-CELLS VIA A PERTUSSIS TOXIN-SENSITIVE MECHANISM [J].
CAULFIELD, MP ;
BROWN, DA .
BRITISH JOURNAL OF PHARMACOLOGY, 1992, 106 (02) :231-232
[7]   Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide [J].
Chemin, J ;
Monteil, A ;
Perez-Reyes, E ;
Nargeot, J ;
Lory, P .
EMBO JOURNAL, 2001, 20 (24) :7033-7040
[8]   MOTOR DEFICIT AND IMPAIRMENT OF SYNAPTIC PLASTICITY IN MICE LACKING MGLUR1 [J].
CONQUET, F ;
BASHIR, ZI ;
DAVIES, CH ;
DANIEL, H ;
FERRAGUTI, F ;
BORDI, F ;
FRANZBACON, K ;
REGGIANI, A ;
MATARESE, V ;
CONDE, F ;
COLLINGRIDGE, GL ;
CREPEL, F .
NATURE, 1994, 372 (6503) :237-243
[9]   Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides [J].
Cravatt, BF ;
Giang, DK ;
Mayfield, SP ;
Boger, DL ;
Lerner, RA ;
Gilula, NB .
NATURE, 1996, 384 (6604) :83-87
[10]  
DEADWYLER SA, 1995, J PHARMACOL EXP THER, V273, P734