Mitochondrial quality control: an integrated network of pathways

被引：206

作者：

Fischer, Fabian ^{[1
]}

Hamann, Andrea ^{[1
]}

Osiewacz, Heinz D. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Fac Biosci & Cluster Excellence Macromol Complexe, Inst Mol Biosci, D-60438 Frankfurt, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2012年 / 37卷 / 07期

关键词：

HUMAN LON PROTEASE; M-AAA PROTEASE; DNA-REPAIR; CELL-DEATH; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; MITOFUSIN; LIFE-SPAN; DEGRADATION; MITOPHAGY;

D O I：

10.1016/j.tibs.2012.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are organelles of eukaryotic cells with various functions. Best known is their role in energy transduction leading to the formation of ATP. As byproducts of this process, reactive oxygen species (ROS) are formed that can damage different types of molecules leading to mitochondria! dysfunction. Different quality control (QC) mechanisms keep mitochondria functional. Although several components involved in mitochondria! QC have been characterized in some detail, others remain to be integrated into what is currently emerging as a hierarchical network of interacting pathways. The elucidation of this network holds the key to the understanding of complex biological processes such as aging and the development of age-related diseases.

引用

收藏

页码：284 / 292

页数：9

相关论文

共 81 条

[31] A Stress-Responsive System for Mitochondrial Protein Degradation [J].

Heo, Jin-Mi ;

Livnat-Levanon, Nurit ;

Taylor, Eric B. ;

Jones, Kevin T. ;

Dephoure, Noah ;

Ring, Julia ;

Xie, Jianxin ;

Brodsky, Jeffrey L. ;

Madeo, Frank ;

Gygi, Steven P. ;

Ashrafi, Kaveh ;

Glickman, Michael H. ;

Rutter, Jared .

MOLECULAR CELL, 2010, 40 (03) :465-480

[32] The machines that divide and fuse mitochondria [J].

Hoppins, Suzanne ;

Lackner, Laura ;

Nunnari, Jodi .

ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 :751-780

[33] Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL [J].

Jin, Seok Min ;

Lazarou, Michael ;

Wang, Chunxin ;

Kane, Lesley A. ;

Narendra, Derek P. ;

Youle, Richard J. .

JOURNAL OF CELL BIOLOGY, 2010, 191 (05) :933-942

[34] Mitophagy in Yeast Occurs through a Selective Mechanism [J].

Kanki, Tomotake ;

Klionsky, Daniel J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (47) :32386-32393

[35] Mitochondrial mutational spectra in human cells and tissues [J].

Khrapko, K ;

Coller, HA ;

Andre, PC ;

Li, XC ;

Hanekamp, JS ;

Thilly, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13798-13803

[36] Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1 [J].

Kieper, Nicole ;

Holmstroem, Kira M. ;

Ciceri, Dalila ;

Fiesel, Fabienne C. ;

Wolburg, Hartwig ;

Ziviani, Elena ;

Whitworth, Alexander J. ;

Martins, L. Miguel ;

Kahle, Philipp J. ;

Krueger, Rejko .

EXPERIMENTAL CELL RESEARCH, 2010, 316 (07) :1213-1224

[37] Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22 [J].

Kim, Hyun-Ju ;

Morrow, Genevieve ;

Westwood, J. Timothy ;

Michaud, Sebastien ;

Tanguay, Robert M. .

EXPERIMENTAL GERONTOLOGY, 2010, 45 (7-8) :611-620

[38] Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation [J].

Kim, Insil ;

Lemasters, John J. .

ANTIOXIDANTS & REDOX SIGNALING, 2011, 14 (10) :1919-1928

[39] MAP-1 and IAP-1, two novel AAA proteases with catalytic sites on opposite membrane surfaces in mitochondrial inner membrane of Neurospora crassa [J].

Klanner, C ;

Prokisch, H ;

Langer, T .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (09) :2858-2869

[40] Protein degradation within mitochondria: Versatile activities of AAA proteases and other peptidases [J].

Koppen, Mirko ;

Langer, Thomas .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 42 (03) :221-242

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