Interaction of trivalent antimony with a CCHC zinc finger domain:: potential relevance to the mechanism of action of antimonial drugs

被引:36
作者
Demicheli, Cynthia [1 ]
Frezard, Frederic [2 ]
Mangrum, John B. [3 ]
Farrell, Nicholas P. [3 ]
机构
[1] Univ Fed Minas Gerais, Dept Quim, ICEX, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Fisol & Biofis, ICB, BR-31270901 Belo Horizonte, MG, Brazil
[3] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA
关键词
D O I
10.1039/b809186b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Sb III competes with Zn II for its binding to the CCHC zinc. nger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.
引用
收藏
页码:4828 / 4830
页数:3
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