The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

被引：112

作者：

Alvarez-Venegas, R

Sadder, M

Hlavacka, A

Baluska, F

Xia, YN

Lu, GQ

Firsov, A

Sarath, G

Moriyama, H

Dubrovsky, JG

Avramova, Z ^{[1
]}

机构：

[1] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA

[2] Univ Bonn, Inst Bot, Dept Plant Cell Biol, D-53115 Bonn, Germany

[3] Univ Nebraska, Ctr Biotechnol, Genom Core Res Facil, Lincoln, NE 68588 USA

[4] Univ Nebraska, Ctr Biotechnol, Bioinformat Core Res Facil, Lincoln, NE 68588 USA

[5] Univ Nebraska, USDA, Agr Res Serv Unit, Lincoln, NE 68583 USA

[6] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

[7] Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 15期

关键词：

epigenetic regulation; lipid signaling;

D O I：

10.1073/pnas.0600944103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

引用

页码：6049 / 6054

页数：6

共 36 条

[11] The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
Gozani, O
Karuman, P
Jones, DR
Ivanov, D
Cha, J
Lugovskoy, AA
Baird, CL
Zhu, H
Field, SJ
Lessnick, SL
Villasenor, J
Mehrotra, B
Chen, J
Rao, VR
Brugge, JS
Ferguson, CG
Payrastre, B
Myszka, DG
Cantley, LC
Wagner, G
Divecha, N
Prestwich, GD
Yuan, JY
[J]. CELL, 2003, 114 (01) : 99 - 111
[12] The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression
Grienenberger, A
Miotto, B
Sagnier, T
Cavalli, G
Schramke, V
Geli, V
Mariol, MC
Berenger, H
Graba, Y
Pradel, J
[J]. CURRENT BIOLOGY, 2002, 12 (09) : 762 - 766
[13] GUI X, 1998, NAT GENET, V18, P331
[14] Linking lipids to chromatin
Jones, DR
Divecha, N
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (02) : 196 - 202
[15] Structural mechanism of endosome docking by the FYVE domain
Kutateladze, T
Overduin, M
[J]. SCIENCE, 2001, 291 (5509) : 1793 - 1796
[16] Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation
Linder, B
Newman, R
Jones, LK
Debernardi, S
Young, BD
Freemont, P
Verrijzer, CP
Saha, V
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 299 (02) : 369 - 378
[17] THE TRITHORAX GENE, A TRANS-ACTING REGULATOR OF THE BITHORAX COMPLEX IN DROSOPHILA, ENCODES A PROTEIN WITH ZINC-BINDING DOMAINS
MAZO, AM
HUANG, DH
MOZER, BA
DAWID, IB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2112 - 2116
[18] Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtIns5P), and its accumulation upon osmotic stress
Meijer, HJG
Berrie, CP
Iurisci, C
Divecha, N
Musgrave, A
Munnik, T
[J]. BIOCHEMICAL JOURNAL, 2001, 360 : 491 - 498
[19] MLL targets SET domain methyltransferase activity to Hox gene promoters
Milne, TA
Briggs, SD
Brock, HW
Martin, ME
Gibbs, D
Allis, CD
Hess, JL
[J]. MOLECULAR CELL, 2002, 10 (05) : 1107 - 1117
[20] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
Mochizuki, Y
Majerus, PW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (17) : 9768 - 9773

← 1 2 3 4 →