Immunological and structural similarities among allergens: Prerequisite for a specific and component-based therapy of allergy

被引：60

作者：

Valenta, R

Steinberger, P

Duchene, M

Kraft, D

机构：

[1] Inst. of Gen. and Exp. Pathology, AKH, University of Vienna

[2] Inst. of Gen. and Exp. Pathology, AKH, University of Vienna, A-1090 Vienna

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1996年 / 74卷 / 02期

关键词：

allergens; cross-reactivity; IgE; therapy; type I allergy;

D O I：

10.1038/icb.1996.26

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is known that allergic patients are frequently co-sensitized against different allergen sources. Progress made in the field of allergen characterization by molecular biological techniques has now revealed that sensitization against different allergen sources can be explained as cross-reactivity of IgE antibodies with structurally and immunologically related components present in these allergen sources. This review defines groups of cross-reactive plant allergens with significant sequence homology. The similarities among allergens may facilitate allergy diagnosis by using a few representative cross-reactive allergens to determine the patient's IgE reactivity profile (allergogram). According to that typing, a few cross-reactive allergens, carrying most of the relevant IgE epitopes, may then be selected for patient-tailored specific therapy.

引用

页码：187 / 194

页数：8

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