The neuropilins: Multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis

被引：273

作者：

Neufeld, G ^{[1
]}

Cohen, T ^{[1
]}

Shraga, N ^{[1
]}

Lange, T ^{[1
]}

Kessler, O ^{[1
]}

Herzog, Y ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Biol, IL-32000 Haifa, Israel

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S1050-1738(01)00140-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuropilin-1 (np1) and neuropilin-2 (np2) receptors function as receptors for the axon guidance factors belonging to the class-3 sema-phorin subfamily. In addition, both neuropilins are able to bind to certain heparin-binding splice forms of vascular endothelial growth factor (VEGF), indicating that both neuropilins have roles in the cardiovascular system as well. Gene targeting experiments indicate that np1 does indeed function as an important modulator of VEGF function during vasculogenesis and angiogenesis, but the role of np2 in the cardiovascular system has not been studied in detail as yet. This review focuses on the neuropilins, their interactions, and their biological roles in the nervous and cardiovascular systems. (C) 2002, Elsevier Science Inc.

引用

页码：13 / 19

页数：7

共 62 条

[1] Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor [J].

Bagnard, D ;

Vaillant, C ;

Khuth, ST ;

Dufay, N ;

Lohrum, M ;

Püschel, AW ;

Belin, MF ;

Bolz, J ;

Thomasset, N .

JOURNAL OF NEUROSCIENCE, 2001, 21 (10) :3332-3341

[2] Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin [J].

Behar, O ;

Mizuno, K ;

Badminton, M ;

Woolf, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13501-13505

[3] Semaphorin III Is needed for normal patterning and growth of nerves, bones and heart [J].

Behar, O ;

Golden, JA ;

Mashimo, H ;

Schoen, FJ ;

Fishman, MC .

NATURE, 1996, 383 (6600) :525-528

[4]

Cai HB, 1999, J NEUROSCI, V19, P6519

[5] Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [J].

Carmeliet, P ;

Ng, YS ;

Nuyens, D ;

Theilmeier, G ;

Brusselmans, K ;

Cornelissen, I ;

Ehler, E ;

Kakkar, VV ;

Stalmans, I ;

Mattot, V ;

Perriard, JC ;

Dewerchin, M ;

Flameng, W ;

Nagy, A ;

Lupu, F ;

Moons, L ;

Collen, D ;

D'Amore, PA ;

Shima, DT .

NATURE MEDICINE, 1999, 5 (05) :495-502

[6] Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance [J].

Castellani, V ;

Chédotal, A ;

Schachner, M ;

Faivre-Sarrailh, C ;

Rougon, G .

NEURON, 2000, 27 (02) :237-249

[7] Neuropilin-2 regulates the development of select cranial and sensory nerves and hippocampal mossy fiber projections [J].

Chen, H ;

Bagri, A ;

Zupicich, JA ;

Zou, YM ;

Stoeckli, E ;

Pleasure, SJ ;

Lowenstein, DH ;

Skarnes, WC ;

Chédotal, A ;

Tessier-Lavigne, M .

NEURON, 2000, 25 (01) :43-56

[8]

Cheng TS, 1997, MRS INTERNET J N S R, V2

[9] Neuroendocrine cells along the digestive tract express neuropilin-2 [J].

Cohen, T ;

Gluzman-Poltorak, Z ;

Brodzky, A ;

Meytal, V ;

Sabo, E ;

Misselevich, I ;

Hassoun, M ;

Boss, JH ;

Resnick, M ;

Shneyvas, D ;

Eldar, S ;

Neufeld, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (02) :395-403

[10]

Crossin KL, 2000, DEV DYNAM, V218, P260, DOI 10.1002/(SICI)1097-0177(200006)218:2<260::AID-DVDY3>3.0.CO

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