Alkylation of phenylglycinol-derived bicyclic lactams.: Enantioselective synthesis of 3-alkylpiperidines

被引：14

作者：

Amat, M ^{[1
]}

Escolano, C ^{[1
]}

Llor, NR ^{[1
]}

Lozano, O ^{[1
]}

Gómez-Esqué, A ^{[1
]}

Griera, R ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, Av Joan XXIII S-N, E-08028 Barcelona, Spain

来源：

ARKIVOC | 2005年

关键词：

chiral bicyclic lactams; phenylglycinol; alkylation; enantioselective synthesis;

D O I：

10.3998/ark.5550190.0006.912

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemical outcome of the alkylation of simple phenylglycinol-derived bicyclic lactams has been studied. The method provides a simple and concise route to 3-alkylpiperidines in both enantiomeric series. The synthesis of (+)-R-decarbomethoxytetrahydrosecodine, an indole alkaloid embodying a 3-ethylpiperidine moiety, is reported.

引用

页码：115 / 123

页数：9

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