N-alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines .8. the scope of tandem reactions involving hydroxylamine-alkyne cyclisations

被引：35

作者：

Davison, EC

Forbes, IT

Holmes, AB

Warner, JA

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 35期

关键词：

D O I：

10.1016/0040-4020(96)00643-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem sequence of hydroxylamine-alkyne cyclisation/1,3-dipolar cycloaddition, provides useful entry into tricyclic systems of type 4. The scope of such reactions is explored in this paper. A novel cascade cyclisation of N-hydroxypyrrolidines of type 26 and 28 involving hydroxylamine-alkyne cyclisation, Cope elimination and 1,3-dipolar cycloaddition is also reported. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：11601 / 11624

页数：24

共 38 条

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