Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates

被引：43

作者：

Bariciak, Erika ^{[1
]}

Yasin, Abeer ^{[2
]}

Harrold, Joann ^{[1
]}

Walker, Mark ^{[3
]}

Lepage, Nathalie ^{[4
]}

Filler, Guido ^{[2
,5
]}

机构：

[1] Univ Ottawa, Dept Pediat, Ottawa, ON K1H 8L1, Canada

[2] Schulich Sch Med & Dent, Dept Pediat, London, ON N6A 5W9, Canada

[3] Univ Ottawa, Ottawa, ON K1H 8L6, Canada

[4] Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON K1H 8L1, Canada

[5] Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON N5A 5A5, Canada

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 13期

关键词：

Cystatin C; Beta trace protein; Creatinine; Neonates; Premature neonates; Reference intervals;

D O I：

10.1016/j.clinbiochem.2011.06.987

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To determine the reference intervals for serum cystatin C (CysC) and beta-trace protein (BTP) as markers of renal function in preterm and term neonates. Design and Methods: Blood samples of 128 neonates (34% female) admitted to the NICU were analyzed to determine the levels of serum creatinine (enzymatically), CysC and BTP (nephelometric, Siemens Health Care). Results: The reference intervals, categorized by age, were reported for the 128 neonates. Median (lower/upper limit) BTP were 1.85 (0.57/3.16) and 1.27 (0.51/2.07) mg/L on days 1 and 3. In keeping with maturation of renal function after birth, CysC and BTP fell from days one to day three after birth, whereas creatinine did not. Conclusion: Our data provides reference intervals for the levels of creatinine, CysC, and BTP in neonates on days 1 and 3 after birth and demonstrates that CysC and BTP reflect neonatal renal function, whereas creatinine reflects maternal renal function. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1156 / 1159

页数：4

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