Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus

被引：52

作者：

Connor, B

Beilharz, EJ

Williams, C

Synek, B

Gluckman, PD

Faull, RJM

Dragunow, M

机构：

[1] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHARMACOL,AUCKLAND 1,NEW ZEALAND

[2] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PEDIAT,AUCKLAND 1,NEW ZEALAND

[3] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PATHOL,AUCKLAND 1,NEW ZEALAND

[4] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT ANAT,AUCKLAND 1,NEW ZEALAND

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 49卷 / 1-2期

关键词：

neurotrophic factor; astrogliosis; senile plaque; beta-amyloid protein; neurodegeneration;

D O I：

10.1016/S0169-328X(97)00192-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-I immunoreactivity was examined in the Alzheimer's disease and normal post-mortem human hippocampus and temporal cortex to determine whether IGF-I protein levels are altered in response to neurodegeneration. IGF-I immunoreactivity was induced in a subpopulation of GFAP-immunopositive astroglia in the Alzheimer's disease temporal cortex. These observations raise the possibility that IGF-I has a neuroprotective role in the Alzheimer's disease brain. (C) 1997 Elsevier Science B.V.

引用

页码：283 / 290

页数：8

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