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Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus

被引：52
作者：
Connor, B
Beilharz, EJ
Williams, C
Synek, B
Gluckman, PD
Faull, RJM
Dragunow, M
机构：
[1] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHARMACOL,AUCKLAND 1,NEW ZEALAND
[2] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PEDIAT,AUCKLAND 1,NEW ZEALAND
[3] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PATHOL,AUCKLAND 1,NEW ZEALAND
[4] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT ANAT,AUCKLAND 1,NEW ZEALAND
来源：
MOLECULAR BRAIN RESEARCH | 1997年 / 49卷 / 1-2期
关键词：
neurotrophic factor; astrogliosis; senile plaque; beta-amyloid protein; neurodegeneration;
D O I：
10.1016/S0169-328X(97)00192-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-I immunoreactivity was examined in the Alzheimer's disease and normal post-mortem human hippocampus and temporal cortex to determine whether IGF-I protein levels are altered in response to neurodegeneration. IGF-I immunoreactivity was induced in a subpopulation of GFAP-immunopositive astroglia in the Alzheimer's disease temporal cortex. These observations raise the possibility that IGF-I has a neuroprotective role in the Alzheimer's disease brain. (C) 1997 Elsevier Science B.V.
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收藏
页码：283 / 290
页数：8
相关论文
共 57 条
  • [11] CHENG B, 1992, J NEUROSCI, V12, P1558
  • [12] Trk receptor alterations in Alzheimer's disease
    Connor, B
    Young, D
    Lawlor, P
    Gai, W
    Waldvogel, H
    Faull, RLM
    Dragunow, M
    [J]. MOLECULAR BRAIN RESEARCH, 1996, 42 (01): : 1 - 17
  • [13] A POTENTIAL ROLE FOR APOPTOSIS IN NEURODEGENERATION AND ALZHEIMERS-DISEASE
    COTMAN, CW
    ANDERSON, AJ
    [J]. MOLECULAR NEUROBIOLOGY, 1995, 10 (01) : 19 - 45
  • [14] INSULIN-LIKE GROWTH FACTOR-I RECEPTOR-BINDING IN BRAINS OF ALZHEIMERS AND ALCOHOLIC PATIENTS
    CREWS, FT
    MCELHANEY, R
    FREUND, G
    BALLINGER, WE
    RAIZADA, MK
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 58 (04) : 1205 - 1210
  • [15] DEKEYSER J, 1994, NEUROSCI LETT, V172, P93
  • [16] THE ROLE OF CORTICAL CONNECTIVITY IN ALZHEIMERS-DISEASE PATHOGENESIS - A REVIEW AND MODEL SYSTEM
    DELACOSTE, MC
    WHITE, CL
    [J]. NEUROBIOLOGY OF AGING, 1993, 14 (01) : 1 - 16
  • [17] IN-SITU EVIDENCE FOR DNA FRAGMENTATION IN HUNTINGTONS-DISEASE STRIATUM AND ALZHEIMERS-DISEASE TEMPORAL LOBES
    DRAGUNOW, M
    FAULL, RLM
    LAWLOR, P
    BEILHARZ, EJ
    SINGLETON, K
    WALKER, EB
    MEE, E
    [J]. NEUROREPORT, 1995, 6 (07) : 1053 - 1057
  • [18] IMMEDIATE-EARLY GENE PROTEIN EXPRESSION IN NEURONS UNDERGOING DELAYED DEATH, BUT NOT NECROSIS, FOLLOWING HYPOXIC-ISCHEMIC INJURY TO THE YOUNG-RAT BRAIN
    DRAGUNOW, M
    BEILHARZ, E
    SIRIMANNE, E
    LAWLOR, P
    WILLIAMS, C
    BRAVO, R
    GLUCKMAN, P
    [J]. MOLECULAR BRAIN RESEARCH, 1994, 25 (1-2): : 19 - 33
  • [19] APOPTOSIS MEDIATED NEUROTOXICITY INDUCED BY CHRONIC APPLICATION OF BETA-AMYLOID FRAGMENT 25-35
    FORLONI, G
    CHIESA, R
    SMIROLDO, S
    VERGA, L
    SALMONA, M
    TAGLIAVINI, F
    ANGERETTI, N
    [J]. NEUROREPORT, 1993, 4 (05) : 523 - 526
  • [20] ASTROGLIA IN ALZHEIMERS-DISEASE
    FREDERICKSON, RCA
    [J]. NEUROBIOLOGY OF AGING, 1992, 13 (02) : 239 - 253
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