Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661

被引：32

作者：

Iso, Y ^{[1
]}

Irie, T ^{[1
]}

Iwaki, T ^{[1
]}

Kii, M ^{[1
]}

Sendo, Y ^{[1
]}

Motokawa, K ^{[1
]}

Nishitani, Y ^{[1
]}

机构：

[1] SHIONOGI & CO LTD,SHIONOGI RES LABS,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 05期

关键词：

D O I：

10.7164/antibiotics.49.478

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

引用

页码：478 / 484

页数：7

共 8 条

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