A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes

被引：25

作者：

Gauguier, D

Kaisaki, PJ

Rouard, M

Wallis, RH

Browne, J

Rapp, JP

Bihoreau, MT

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43699 USA

来源：

MAMMALIAN GENOME | 1999年 / 10卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/s003359901070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the localization by linkage analysis in the rat genome of 148 new markers derived from 128 distinct known gene sequences. ESTs, and anonymous sequences selected in GenBank database on the basis of the presence of a repeated element. The composite linkage map of the rat contributed by our group integrates mapping information on a total of 370 different known genes, ESTs, and anonymous mouse or human sequences, and provides a valuable tool for comparative genome analysis. 206 and 254 homologous loci were identified in the mouse and human genomes respectively. Our linkage map, which combines both anonymous markers and gene markers, should facilitate the advancement of genetic studies fur a wide variety of rat models characterized for complete phenotypes. The comparative genome mapping should define genetic regions in human likely to be homologous to susceptibility loci identified in rat and provide useful information for the identification of new potential candidates for genetic disorders.

引用

收藏

页码：675 / 686

页数：12

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