Mechanisms of Mediator complex action in transcriptional activation

被引：79

作者：

Ansari, Suraiya A. ^{[1
]}

Morse, Randall H. ^{[1
,2
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Mol Genet Lab, Albany, NY 12201 USA

[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 15期

基金：

美国国家科学基金会;

关键词：

Transcription; Mediator; Co-activator; SAGA; Swi/Snf; RNA-POLYMERASE-II; IN-VIVO TARGET; TERMINAL REPEAT DOMAIN; TATA-BINDING PROTEIN; YEAST MEDIATOR; SRB MEDIATOR; SACCHAROMYCES-CEREVISIAE; INDEPENDENT RECRUITMENT; DEPENDENT TRANSCRIPTION; COACTIVATOR COMPLEX;

D O I：

10.1007/s00018-013-1265-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mediator is a large multisubunit complex that plays a central role in the regulation of RNA Pol II transcribed genes. Conserved in overall structure and function among eukaryotes, Mediator comprises 25-30 protein subunits that reside in four distinct modules, termed head, middle, tail, and CDK8/kinase. Different subunits of Mediator contact other transcriptional regulators including activators, co-activators, general transcription factors, subunits of RNA Pol II, and specifically modified histones, leading to the regulated expression of target genes. This review is focused on the interactions of specific Mediator subunits with diverse transcription regulators and how those interactions contribute to Mediator function in transcriptional activation.

引用

页码：2743 / 2756

页数：14

共 163 条

[1] Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor α-dependent transcription with chromatin templates [J].

Acevedo, ML ;

Kraus, WL .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (01) :335-348

[2] TFIIH is negatively regulated by cdk8-containing mediator complexes [J].

Akoulitchev, S ;

Chuikov, S ;

Reinberg, D .

NATURE, 2000, 407 (6800) :102-106

[3] Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA [J].

Andrau, JC ;

van de Pasch, L ;

Lijnzaad, P ;

Bijma, T ;

Koerkamp, MG ;

van de Peppel, J ;

Werner, M ;

Holstege, FCP .

MOLECULAR CELL, 2006, 22 (02) :179-192

[4] Mediator Acts Upstream of the Transcriptional Activator Gal4 [J].

Ang, Keven ;

Ee, Gary ;

Ang, Edwin ;

Koh, Elvin ;

Siew, Wee Leng ;

Chan, Yu Mun ;

Nur, Sabrina ;

Tan, Yee Sun ;

Lehming, Norbert .

PLOS BIOLOGY, 2012, 10 (03)

[5] Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast [J].

Ansari, Suraiya A. ;

Ganapathi, Mythily ;

Benschop, Joris J. ;

Holstege, Frank C. P. ;

Wade, Joseph T. ;

Morse, Randall H. .

EMBO JOURNAL, 2012, 31 (01) :44-57

[6] Mediator complex association with constitutively transcribed genes in yeast [J].

Ansari, Suraiya A. ;

He, Qiye ;

Morse, Randall H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (39) :16734-16739

[7] Conserved structures of mediator and RNA polymerase II holoenzyme [J].

Asturias, FJ ;

Jiang, YW ;

Myers, LC ;

Gustafsson, CM ;

Kornberg, RD .

SCIENCE, 1999, 283 (5404) :985-987

[8] Cell numbers and leaf development in Arabidopsis:: a functional analysis of the STRUWWELPETER gene [J].

Autran, D ;

Jonak, C ;

Belcram, K ;

Beemster, GTS ;

Kronenberger, J ;

Grandjean, O ;

Inzé, D ;

Traas, J .

EMBO JOURNAL, 2002, 21 (22) :6036-6049

[9] Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit [J].

Backstrom, Stefan ;

Elfving, Nils ;

Nilsson, Robert ;

Wingsle, Gunnar ;

Bjorklund, Stefan .

MOLECULAR CELL, 2007, 26 (05) :717-729

[10] Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAFIIs [J].

Baek, HJ ;

Malik, S ;

Qin, J ;

Roeder, RG .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (08) :2842-2852

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