Mechanisms of Mediator complex action in transcriptional activation

被引:79
作者
Ansari, Suraiya A. [1 ]
Morse, Randall H. [1 ,2 ]
机构
[1] New York State Dept Hlth, Wadsworth Ctr, Mol Genet Lab, Albany, NY 12201 USA
[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA
基金
美国国家科学基金会;
关键词
Transcription; Mediator; Co-activator; SAGA; Swi/Snf; RNA-POLYMERASE-II; IN-VIVO TARGET; TERMINAL REPEAT DOMAIN; TATA-BINDING PROTEIN; YEAST MEDIATOR; SRB MEDIATOR; SACCHAROMYCES-CEREVISIAE; INDEPENDENT RECRUITMENT; DEPENDENT TRANSCRIPTION; COACTIVATOR COMPLEX;
D O I
10.1007/s00018-013-1265-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mediator is a large multisubunit complex that plays a central role in the regulation of RNA Pol II transcribed genes. Conserved in overall structure and function among eukaryotes, Mediator comprises 25-30 protein subunits that reside in four distinct modules, termed head, middle, tail, and CDK8/kinase. Different subunits of Mediator contact other transcriptional regulators including activators, co-activators, general transcription factors, subunits of RNA Pol II, and specifically modified histones, leading to the regulated expression of target genes. This review is focused on the interactions of specific Mediator subunits with diverse transcription regulators and how those interactions contribute to Mediator function in transcriptional activation.
引用
收藏
页码:2743 / 2756
页数:14
相关论文
共 163 条
[91]   Independent recruitment of mediator and SAGA by the activator Met4 [J].
Leroy, C ;
Cormier, L ;
Kuras, L .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (08) :3149-3163
[92]   The mediator coactivator complex: functional and physical roles in transcriptional regulation [J].
Lewis, BA ;
Reinberg, D .
JOURNAL OF CELL SCIENCE, 2003, 116 (18) :3667-3675
[93]   The role of chromatin during transcription [J].
Li, Bing ;
Carey, Michael ;
Workman, Jerry L. .
CELL, 2007, 128 (04) :707-719
[94]   Enhancement of TBP binding by activators and general transcription factors [J].
Li, XY ;
Virbasius, A ;
Zhu, XC ;
Green, MR .
NATURE, 1999, 399 (6736) :605-609
[95]   Mediator coordinates PIC assembly with recruitment of CHD1 [J].
Lin, Justin J. ;
Lehmann, Lynn W. ;
Bonora, Giancarlo ;
Sridharan, Rupa ;
Vashisht, Ajay A. ;
Tran, Nancy ;
Plath, Kathrin ;
Wohlschlegel, James A. ;
Carey, Michael .
GENES & DEVELOPMENT, 2011, 25 (20) :2198-2209
[96]   Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4 [J].
Lin, Ling ;
Chamberlain, Lynn ;
Zhu, Lihua J. ;
Green, Michael R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (06) :1997-2002
[97]   STAGA recruits mediator to the MYC oncoprotein to stimulate transcription and cell proliferation [J].
Liu, Xiaohui ;
Vorontchikhina, Marina ;
Wang, Yuan-Liang ;
Faiola, Francesco ;
Martinez, Ernest .
MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (01) :108-121
[98]   Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions [J].
Liu, Zhongle ;
Myers, Lawrence C. .
PLOS ONE, 2012, 7 (06)
[99]   Mediator-nucleosome interaction [J].
Lorch, Y ;
Beve, J ;
Gustafsson, CM ;
Myers, LC ;
Kornberg, RD .
MOLECULAR CELL, 2000, 6 (01) :197-201
[100]   FUSION OF GAL4-VP16 TO A STEROID-BINDING DOMAIN PROVIDES A TOOL FOR GRATUITOUS INDUCTION OF GALACTOSE-RESPONSIVE GENES IN YEAST [J].
LOUVION, JF ;
HAVAUXCOPF, B ;
PICARD, D .
GENE, 1993, 131 (01) :129-134