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The role of chromatin during transcription

被引：2687
作者：
Li, Bing
Carey, Michael
Workman, Jerry L.
机构：
[1] Stowers Med Res Inst, Kansas City, MO 64110 USA
[2] Univ Calif Los Angeles, Dept Biol Chem, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
CELL | 2007年 / 128卷 / 04期
关键词：
D O I：
10.1016/j.cell.2007.01.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription. © 2007 Elsevier Inc. All rights reserved.
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页码：707 / 719
页数：13
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