Tissue factor in hemostasis and thrombosis

被引：65

作者：

Tilley, R

Mackman, N

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2006年 / 32卷 / 01期

关键词：

tissue factor; hemostasis; thrombosis; procoagulant; anticoagulant;

D O I：

10.1055/s-2006-933335

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue factor (TF) plays all essential role in hemostasis. The tissue-specific pattern of TF expression is consistent with additional hemostatic protection in vital organs. An aberrant expression of TF within the vasculature Occurs in a variety of diseases, including atherosclerosis, cancer, and sepsis. TF expression in these diseases is associated with thrombotic events. Future therapeutic strategies may prove beneficial in the treatment of thrombosis. However, these strategies should be designed to avoid compromising hemostasis.

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收藏

页码：5 / 10

页数：6

相关论文

共 41 条

[1] DIFFERENTIAL EXPRESSION OF TISSUE FACTOR PROTEIN IN DIRECTIONAL ATHERECTOMY SPECIMENS FROM PATIENTS WITH STABLE AND UNSTABLE CORONARY SYNDROMES [J].

ANNEX, BH ;

DENNING, SM ;

CHANNON, KM ;

SKETCH, MH ;

STACK, RS ;

MORRISSEY, JH ;

PETERS, KG .

CIRCULATION, 1995, 91 (03) :619-622

[2] Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia [J].

Aras, O ;

Shet, A ;

Bach, RR ;

Hysjulien, JL ;

Slungaard, A ;

Hebbel, RP ;

Escolar, G ;

Jilma, B ;

Key, NS .

BLOOD, 2004, 103 (12) :4545-4553

[3] Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques - Effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions [J].

Badimon, JJ ;

Lettino, M ;

Toschi, V ;

Fuster, V ;

Berrozpe, M ;

Chesebro, JH ;

Badimon, L .

CIRCULATION, 1999, 99 (14) :1780-1787

[4] Thrombophilia and fetal loss [J].

Brenner, B .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2003, 29 (02) :165-170

[5]

CALLANDER NS, 1992, CANCER-AM CANCER SOC, V70, P1194, DOI 10.1002/1097-0142(19920901)70:5<1194::AID-CNCR2820700528>3.0.CO

[6]

2-E

[7]

Chaddha Vandana, 2004, Semin Fetal Neonatal Med, V9, P357, DOI 10.1016/j.siny.2004.03.006

[8] Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation [J].

Chou, J ;

Mackman, N ;

Merrill-Skoloff, G ;

Pedersen, B ;

Furie, BC ;

Furie, B .

BLOOD, 2004, 104 (10) :3190-3197

[9] In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease [J].

Contrino, J ;

Hair, G ;

Kreutzer, DL ;

Rickles, FR .

NATURE MEDICINE, 1996, 2 (02) :209-215

[10] TISSUE FACTOR PATHWAY INHIBITOR REDUCES MORTALITY FROM ESCHERICHIA-COLI SEPTIC SHOCK [J].

CREASEY, AA ;

CHANG, ACK ;

FEIGEN, L ;

WUN, TC ;

TAYLOR, FB ;

HINSHAW, LB .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2850-2860

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