Tissue factor in hemostasis and thrombosis

被引：65

作者：

Tilley, R

Mackman, N

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2006年 / 32卷 / 01期

关键词：

tissue factor; hemostasis; thrombosis; procoagulant; anticoagulant;

D O I：

10.1055/s-2006-933335

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue factor (TF) plays all essential role in hemostasis. The tissue-specific pattern of TF expression is consistent with additional hemostatic protection in vital organs. An aberrant expression of TF within the vasculature Occurs in a variety of diseases, including atherosclerosis, cancer, and sepsis. TF expression in these diseases is associated with thrombotic events. Future therapeutic strategies may prove beneficial in the treatment of thrombosis. However, these strategies should be designed to avoid compromising hemostasis.

引用

收藏

页码：5 / 10

页数：6

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