FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

被引：244

作者：

Xie, MH

Holcomb, I

Deuel, B

Dowd, P

Huang, A

Vagts, A

Foster, J

Liang, J

Brush, J

Gu, QM

Hillan, K

Goddard, A

Gurney, AL

机构：

[1] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA

来源：

CYTOKINE | 1999年 / 11卷 / 10期

关键词：

cartilage; cytokine; FGF19; FGFR4; FGF;

D O I：

10.1006/cyto.1999.0485

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. (C) 1999 Academic Press.

引用

页码：729 / 735

页数：7

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