Endogenous small RNAs in grain: Semi-quantification and sequence homology to human and animal genes

被引：38

作者：

Ivashuta, Sergey I. ^{[1
]}

Petrick, Jay S. ^{[1
]}

Heisel, Sara E. ^{[1
]}

Zhang, Yuanji ^{[1
]}

Guo, Liang ^{[1
]}

Reynolds, Tracey L. ^{[1
]}

Rice, James F. ^{[1
]}

Allen, Edwards ^{[1
]}

Roberts, James K. ^{[1
]}

机构：

[1] Monsanto Co, St Louis, MO 63167 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 02期

关键词：

RNAi; Small RNA; siRNA; miRNA; Crops; History of safe consumption; IN-VIVO STABILITY; ARTIFICIAL MICRORNAS; TRANSGENIC PLANTS; TOMATO; SAFETY; PHOSPHOROTHIOATE; ABSORPTION; ALLERGEN; FOODS; SIRNA;

D O I：

10.1016/j.fct.2008.11.025

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are effector molecules of RNA interference (RNAi), a highly conserved RNA-based gene suppression mechanism in plants, mammals and other eukaryotes. Endogenous RNAi-based gene suppression has been harnessed naturally and through conventional breeding to achieve desired plant phenotypes. The present study demonstrates that endogenous small RNAs, such as siRNAs and miRNAs, are abundant in soybean seeds, corn kernels, and rice grain, plant tissues that are traditionally used for food and feed. Numerous enclogenous plant small RNAs were found to have perfect complementarity to human genes as well as those of other mammals. The abundance of enclogenous small RNA molecules in grain from safely consumed food and feed crops such as soybean, corn, and rice and the homology of a number of these dietary small RNAs to human and animal genomes and transcriptomes establishes a history of safe consumption for dietary small RNAs. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：353 / 360

页数：8

共 61 条

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ABSORPTION, TISSUE DISTRIBUTION AND IN-VIVO STABILITY IN RATS OF A HYBRID ANTISENSE OLIGONUCLEOTIDE FOLLOWING ORAL-ADMINISTRATION [J].