Have archaeal genes contributed to bacterial virulence?

被引：29

作者：

Gophna, U

Charlebois, RL

Doolittle, WF

机构：

[1] Dalhousie Univ, Genome Atlantic & Dept Biolchem & Mol Biol, Halifax, NS B3H 4B5, Canada

[2] NeuroGadgets Inc, Ottawa, ON K1G 4B5, Canada

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 05期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.tim.2004.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although archaea have not been described as pathogens, it has recently been suggested that genes transferred from archaea might specifically contribute to bacterial virulence. Here, we survey 73 genomes of bacterial pathogens for the presence of genes originating from archaea. We describe 43 cases in which acquisition of archaeal genes by bacterial pathogens can be demonstrated. Although no bona fide virulence factors are among these acquired genes, several of them probably affect pathogen-host interactions.

引用

收藏

页码：213 / 219

页数：7

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