Reduced mastication stimulates impairment of spatial memory and degeneration of hippocampal neurons in aged SAMP8 mice

被引：137

作者：

Onozuka, M

Watanabe, K

Mirbod, SM

Ozono, S

Nishiyama, K

Karasawa, N

Nagatsu, L

机构：

[1] Gifu Univ, Sch Med, Dept Anat, Div 2, Gifu 5008705, Japan

[2] Gifu Univ, Sch Med, Dept Physiol, Gifu 500, Japan

[3] Gifu Univ, Sch Med, Dept Hyg, Gifu 500, Japan

[4] Kanagawa Dent Coll, Dept Oral Biochem, Yokosuka, Kanagawa 238, Japan

[5] Fujita Hlth Univ, Sch Med, Dept Anat, Toyoake, Aichi 47011, Japan

来源：

BRAIN RESEARCH | 1999年 / 826卷 / 01期

关键词：

mastication; aging; hippocampus; neuronal degeneration; learning and memory;

D O I：

10.1016/S0006-8993(99)01255-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of reduced mastication in senile dementia was evaluated by examining the effect of cutting off the upper molars (molarless) on spatial memory and numbers of hippocampal neurons in aged SAMP8 mice. Molarless mice showed a decrease in both learning ability in a water maze and neuron density in the hippocampal CA1 region compared with control mice. These changes increased the longer the molarless condition persisted. The data suggest a possible link between reduced mastication and hippocampal neuron loss that may be one risk factor for senile impairment of spatial memory. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：148 / 153

页数：6

共 26 条

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