Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis

被引：9

作者：

Cottagnoud, P ^{[1
]}

Acosta, F

Cottagnoud, M

Pfister, M

Täuber, MG

机构：

[1] Inselspital Bern, Dept Internal Med, Bern, Switzerland

[2] Zieglerspital Bern, Dept Internal Med, Bern, Switzerland

[3] Univ Bern, Inst Infect Dis, Bern, Switzerland

[4] Univ Calif San Francisco, Dept Lab Med & Biopharmaceut Sci, San Francisco, CA 94143 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 01期

关键词：

D O I：

10.1128/AAC.46.1.184-187.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activity (-0.82 +/- 0.22 Delta log(10) CFU/ml (.) h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain. BMS 284756 monotherapy had a greater potency than the standard regimen of ceftriaxone and vancomycin (-0.49 +/- 0.08 Delta log(10) CFU/ml (.) h) against a penicillin-resistant strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, BMS 284756 showed good bactericidal activity (-0.52 +/- 0.12 Delta log(10) CFU/ml (.) h). The antibacterial activity of BMS 284756 was confirmed by time-killing assays over 8 h in vitro.

引用

页码：184 / 187

页数：4

共 18 条

[1] A critical evaluation of vancomycin for treatment of bacterial meningitis [J].

Ahmed, A .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1997, 16 (09) :895-903

[2] Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children [J].

Anderson, BJ ;

Holford, NHG ;

Woollard, GA ;

Chan, PLS .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 46 (03) :237-243

[3] THE NONMEM SYSTEM [J].

BEAL, S ;

SHEINER, L .

AMERICAN STATISTICIAN, 1980, 34 (02) :118-119

[4]

BENETT JE, 1996, J PHARMACOKINET BIOP, V4, P403

[5] Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro [J].

Cottagnoud, P ;

Acosta, F ;

Cottagnoud, M ;

Neftel, K ;

Täuber, MG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2179-2181

[6] EFFECT OF PROBENECID ON CEREBROSPINAL-FLUID CONCENTRATIONS OF PENICILLIN AND CEPHALOSPORIN DERIVATIVES [J].

DACEY, RG ;

SANDE, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 6 (04) :437-441

[7] EVALUATION OF ANTIMICROBIAL REGIMENS FOR TREATMENT OF EXPERIMENTAL PENICILLIN-RESISTANT AND CEPHALOSPORIN-RESISTANT PNEUMOCOCCAL MENINGITIS [J].

FRIEDLAND, IR ;

PARIS, M ;

EHRETT, S ;

HICKEY, S ;

OLSEN, K ;

MCCRACKEN, GH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1630-1636

[8] Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro [J].

Gerber, CM ;

Cottagnoud, M ;

Neftel, K ;

Täuber, MG ;

Cottagnoud, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (01) :63-68

[9] Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model [J].

Gerber, CM ;

Tovar, L ;

Cottagnoud, M ;

Neftel, KA ;

Täuber, MG ;

Cottagnoud, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (02) :249-253

[10]

Jacobs Michael R., 1999, American Journal of Medicine, V106, p19S, DOI 10.1016/S0002-9343(98)00351-9

← 1 2 →