ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics

被引：189

作者：

Howe, Douglas G. ^{[1
]}

Bradford, Yvonne M. ^{[1
]}

Conlin, Tom ^{[1
]}

Eagle, Anne E. ^{[1
]}

Fashena, David ^{[1
]}

Frazer, Ken ^{[1
]}

Knight, Jonathan ^{[1
]}

Mani, Prita ^{[1
]}

Martin, Ryan ^{[1
]}

Moxon, Sierra A. Taylor ^{[1
]}

Paddock, Holly ^{[1
]}

Pich, Christian ^{[1
]}

Ramachandran, Sridhar ^{[1
]}

Ruef, Barbara J. ^{[1
]}

Ruzicka, Leyla ^{[1
]}

Schaper, Kevin ^{[1
]}

Shao, Xiang ^{[1
]}

Singer, Amy ^{[1
]}

Sprunger, Brock ^{[1
]}

Van Slyke, Ceri E. ^{[1
]}

Westerfield, Monte ^{[1
]}

机构：

[1] 5291 Univ Oregon, ZFIN, Eugene, OR 97403 USA

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/nar/gks938

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures and publications. Integrated views of these data, as well as data gathered through collaborations and data exchanges, are provided through a wide selection of web-based search forms. Among the vertebrate model organisms, zebrafish are uniquely well suited for rapid and targeted generation of mutant lines. The recent rapid production of mutants and transgenic zebrafish is making management of data associated with these resources particularly important to the research community. Here, we describe recent enhancements to ZFIN aimed at improving our support for mutant and transgenic lines, including (i) enhanced mutant/transgenic search functionality; (ii) more expressive phenotype curation methods; (iii) new downloads files and archival data access; (iv) incorporation of new data loads from laboratories undertaking large-scale generation of mutant or transgenic lines and (v) new GBrowse tracks for transgenic insertions, genes with antibodies and morpholinos.

引用

页码：D854 / D860

页数：7

共 8 条

[1]

Busch-Nentwich E., 2010, SANGER I ZEBRAFISH M

[2]

Busch-Nentwich E., 2012, Sanger Institute Zebrafish Mutation Project phenotype and image data submission

[3]

Clark KJ, 2011, NAT METHODS, V8, P506, DOI [10.1038/NMETH.1606, 10.1038/nmeth.1606]

[4]

Ekker S. C., 2012, CURATION ZFISHBOOK L

[5] Integrating phenotype ontologies across multiple species [J].

Mungall, Christopher J. ;

Gkoutos, Georgios V. ;

Smith, Cynthia L. ;

Haendel, Melissa A. ;

Lewis, Suzanna E. ;

Ashburner, Michael .

GENOME BIOLOGY, 2010, 11 (01)

[6] Pathbase and the MPATH Ontology: Community Resources for Mouse Histopathology [J].

Schofield, P. N. ;

Gruenberger, M. ;

Sundberg, J. P. .

VETERINARY PATHOLOGY, 2010, 47 (06) :1016-1020

[7] Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions [J].

Wang, Dongmei ;

Jao, Li-En ;

Zheng, Naizhong ;

Dolan, Kyle ;

Ivey, Jessica ;

Zonles, Seth ;

Wul, Xiaolin ;

Wu, Kangmai ;

Yang, Hongbo ;

Meng, Qingchao ;

Zhu, Zuoyan ;

Zhang, Bo ;

Lin, Shuo ;

Burgess, Shawn M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (30) :12428-12433

[8]

ZF-MODELS Consortium, 2007, ZF MODELS CONS ZEBR

← 1 →