Integrating phenotype ontologies across multiple species

被引：188

作者：

Mungall, Christopher J. ^{[1
]}

Gkoutos, Georgios V. ^{[2
]}

Smith, Cynthia L. ^{[3
]}

Haendel, Melissa A. ^{[4
]}

Lewis, Suzanna E. ^{[1
]}

Ashburner, Michael ^{[2
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Dynam Dept, Berkeley, CA 94720 USA

[2] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[3] Jackson Lab, Bar Harbor, ME 04609 USA

[4] Univ Oregon, Zebrafish Informat Network, Eugene, OR 97403 USA

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

TOOL; INFORMATION; FRAMEWORK; DATABASE; SUPPORT; GENOME; MODEL;

D O I：

10.1186/gb-2010-11-1-r2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

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页数：16

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